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#Modafinil counteract speediness trial#

Have the smallest dose of pills prescribed to you.

Y our physician may suggest a moderate dose reduction rather than abrupt discontinuation.

8,10 Provigil Tapering Guidelines Include: 7 Too much or too little glutamate in the brain can have significant health consequences, such as cellular death by excitotoxicity, and should be monitored. There may also be possible changes to glutamate levels in the body, according to a rat study published in Neuroreport, in 1997. There could also be mood alterations, as well as changes in perception and thoughts, typically characteristic of withdrawal from other stimulant drugs. As noted above, fatigue and depression are features of Provigil withdrawal. Provigil is considered easier to taper off than most SSRI antidepressants due to the neurochemicals involved. 2 The withdrawal from Provigil will occur quite soon after a tapering step. The managing physician may need to cut the pills, which for Provigil means cutting the lowest dosage (100mg white oval tablets) in half, or smaller, as needed. Holistic practitioners will lean more toward addressing root causes with holistic protocols, rather than simply dampening the withdrawals with other medications. The safest method of tapering Provigil is in an inpatient setting, but at least under the care of a prescribing physician who has familiarity with what to expect and who can manage the withdrawal with confidence. Provigil Tapering Guidelines and Schedule It seems more research is needed about modafinil and the human CNS before any reliable conclusions can be drawn about safety and drug effects, especially since the mechanics of how the drug works are not known.

#Modafinil counteract speediness trial#

There have been hundreds of trials on rats, mice, cats, and monkeys, but only one trial was found on humans, as mentioned above, from the FDA drug label. Multiple US states have sued the drugmaker for promoting the prescription drug for off-label uses, but the practice continues. These included depression, muscular sclerosis, Parkinson’s, CFS, and ADHD. In fact, about 90% of Provigil (modafinil) prescriptions were reportedly for off-label treatment of conditions according to the study authors. According to a study by Penalosa et al on US modafinil prescribing trends, there was a 15-fold increase in off-label prescriptions from 2002 to 2009.

2,4 According to the FDA drug label, Provigil produces euphoric and psychoactive effects similar to those of Ritalin or other stimulant drugs in humans. Provigil is a CNS stimulant, sometimes referred to as a CED (cognitive enhancing drug) that was FDA approved for the treatment of narcolepsy, “shift-work disorder,” and sleep apnea. Provigil is the brand name for the generic medication modafinil. More information on methods used to repair and restore health is given below and by visiting Provigil alternatives on our website. 5Īlternative to Meds takes a different approach before, during, and after Provigil tapering by strategically addressing root causes for the original symptoms that had led to drug use in the first place. Provigil tapering was accomplished over a one-month period of time, reducing the dosage by 100mg every few days, along with bupropion and clonazepam to counter the extreme depression and amotivation (lethargy) the patient was experiencing. The withdrawal was difficult and required multiple other prescription drugs to mitigate the withdrawal symptoms. To stay awake on his 12-hour work shift, his dependence eventually led him to take modafinil hourly. His dependence on the stimulant was reportedly characterized by worsened lethargy, tremors, anxiety, and erratic sleep hours when he skipped the medication. 2 However, a study in 2015 published in the Journal of Pharmacology and Pharmacotherapeutics reported the case of a 44-yr-old male who had become dependent on modafinil, the generic version of Provigil. The FDA drug label for Provigil reports that after a single 9-week drug trial, no withdrawal symptoms were reported during the 14-day post-trial monitoring period after the drug was discontinued. Certainly, there is a lack of exhaustive reports on phenomena associated with Provigil tapering or withdrawal. Despite the drug being marketed for some 23 years at present, there is limited clinical literature available on Provigil tapering.